How did the main sequence lifetime of a 100-solar-mass Population III star compare to the Sun's expected lifetime?
They survived for only a few million years.
A fundamental relationship in stellar physics links a star's mass directly to its rate of fuel consumption and, consequently, its lifespan. Because Population III stars were hundreds of times more massive than the Sun, they operated at tremendously higher internal temperatures and pressures. This resulted in hydrogen fuel being burned at a ferocious pace—a star 100 times the mass of the Sun can burn its fuel a million times faster than the Sun. While the Sun has an expected life of about 10 billion years, these primordial giants were predicted to exhaust their fuel and meet their explosive ends in only a few million years, representing an incredibly short cosmic existence.

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