What physical condition forces massive stars to consume hydrogen fuel at a dramatically accelerated rate?

Significantly higher core temperature and pressure must exist to counteract the immense inward gravitational squeeze.

The primary consequence of having high stellar mass is the immense gravitational force pulling inward towards the core. To prevent catastrophic collapse and maintain hydrostatic equilibrium, the stellar core of a massive star must generate far greater internal pressure and sustain a much higher temperature than that found in a smaller star, like the Sun. This heightened thermal and pressure environment directly translates into a dramatically increased kinetic energy for the hydrogen nuclei, causing them to collide and fuse much more frequently and rapidly. This higher fusion rate is precisely what generates the extreme luminosity characteristic of these stars but depletes their fuel supply swiftly.