Persistent changes in which resident immune cells of the central nervous system are observed as a sustained inflammatory state linked to cognitive decline?
Answer
Microglial activation states
Microglia are recognized as the resident immune cells of the central nervous system, acting as the primary surveillance and cleanup crew within the brain environment. Research indicates that radiation exposure can induce persistent changes in the activation states of these microglia. This sustained altered state suggests the immune system’s response is not merely a temporary reaction to shock but a 'reboot' into a long-term, potentially maladaptive, pro-inflammatory state. This chronic inflammatory environment is strongly suspected as the linking factor that translates physical radiation damage into measurable cognitive deficits over time.
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