How does the density of the lowest-density regions of the ISM compare to the density of air we inhale?
Answer
ISM density is far lower than the best vacuum achievable on Earth
The Interstellar Medium is characterized by extreme rarefaction, making its density far lower than even the most advanced vacuums created in terrestrial laboratories. For instance, the air inhaled by a person contains approximately $10^{19}$ molecules per cubic centimeter. In contrast, the lowest-density regions of the ISM exhibit a density of only about $0.1$ atoms per cubic centimeter. This vast difference highlights how empty the majority of interstellar space truly is, although the total mass accumulated over galactic volumes remains substantial.

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