What major handling drawback makes liquid hydrogen (LH2) less favorable than methane for deep-space missions?

Answer

It has an extremely low boiling point (-253°C) and very low density.

Liquid hydrogen is exceptionally difficult to handle due to its extremely low boiling point and its very low density, which necessitates massive and heavy propellant tanks.

What major handling drawback makes liquid hydrogen (LH2) less favorable than methane for deep-space missions?

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